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Home Financial Markets

Modeling Patient Irrationality

Daily Remedy by Daily Remedy
August 8, 2021
in Financial Markets
0

In chess, there is an infinite number of movements and combinations, but only one optimal sequence. Likewise, for any decision, there is an infinite number of pathways, but only one optimal sequence.

So from a probability standpoint, it is more likely that a suboptimal decision will be made instead of an optimal decision.

This may explain why irrational behavior is so commonly seen – it is just more likely.

But for most healthcare insurances, and the actuaries who work for these companies modeling the financial remuneration for clinical services, the models assume patients behavior rationally – that patients consistently make optimal decisions regarding their health.

Clearly there is a conceptual disconnect – beginning with the very concept of optimal itself.

What is optimal to a patient who would rather binge eat at night rather than cope with her stress, willing to suffer obesity in the process?

What is optimal to a rural family that distrusts their local healthcare system and refuses the COVID-19 vaccine in the midst of a pandemic outbreak?

Patient decision-making is guided by intuition; there is no absolute right or wrong for all patients. Rather there are relative benefits and costs, as most medical decisions are an opportunity cost.

A hyper-vigilant patient with hypertension is willing to take the necessary time to organize the medications, taking them daily, and to make the necessary behavioral changes in order to avoid a hypertensive spike.

Many of us are not willing to do so – and knowingly accept the risks of hypertension.

What then is optimal?

It is a relative decision each of us make, daily, weighing the decision in the moment with the short term and long term implications of our health – often with little to no foresight taken.

Behavioral economics have studied this phenomenon, calling it K-level thinking, in reference to the number of conceptual iterations taken before making a decision. Most people are either a K-level zero or one, meaning we either make decisions without thinking or with little thought ahead of time. Few possess higher K-level thinking, which means few fully think through their decisions when making them.

So what is optimal in a world of healthcare where patients make impromptu decisions as opportunity costs – balancing a relative benefit against a relative cost?

It is definitively not rational, like most insurance models would define rational.

It is intuitive, a relative decision, specific to the context in which a patient makes a decision, with little foresight.

Fortunately we have models that approximate this form of thinking.

These models are more complex than the models healthcare insurance companies currently use and integrate probability and spontaneity into the decision-making.

Unfortunately, most insurance companies fail to incorporate these realistic tendencies into the models.

Instead, insurance companies doggedly adhere to antiquated models and antiquated beliefs of patient behavior – living in an era when homo economicus was the model for economic thought.

We now live in a post-rational era, in which the study of irrationality has supplanted the study of a rational economic model.

But insurance companies refuse to accept this new reality, preferring to impose prior authorizations and variable deduction rates against insurers instead of a more realistic model of patient behavior – willing to impose the headache they cause patients.

But it does not have to be this way. Prior authorizations and variable deduction rates are glorified error mechanisms for models that poorly approximate how patients think, decide, and behave overall.

Mechanisms we could eliminate if the models better predicted patient behavior, with greater accuracy – more realistically.

But that would require insurance companies to think rationally about patient behavior – to acknowledge the irrational.

Perhaps that is itself, irrational.

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Daily Remedy

Dr. Jay K Joshi serves as the editor-in-chief of Daily Remedy. He is a serial entrepreneur and sought after thought-leader for matters related to healthcare innovation and medical jurisprudence. He has published articles on a variety of healthcare topics in both peer-reviewed journals and trade publications. His legal writings include amicus curiae briefs prepared for prominent federal healthcare cases.

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Videos

This conversation focuses on debunking myths surrounding GLP-1 medications, particularly the misinformation about their association with pancreatic cancer. The speaker emphasizes the importance of understanding clinical study designs, especially the distinction between observational studies and randomized controlled trials. The discussion highlights the need for patients to critically evaluate the sources of information regarding medication side effects and to empower themselves in their healthcare decisions.

Takeaways
GLP-1 medications are not linked to pancreatic cancer.
Peer-reviewed studies debunk misinformation about GLP-1s.
Anecdotal evidence is not reliable for general conclusions.
Observational studies have limitations in generalizability.
Understanding study design is crucial for evaluating claims.
Symptoms should be discussed in the context of clinical conditions.
Not all side effects reported are relevant to every patient.
Observational studies can provide valuable insights but are context-specific.
Patients should critically assess the relevance of studies to their own experiences.
Engagement in discussions about specific studies can enhance understanding

Chapters
00:00
Debunking GLP-1 Medication Myths
02:56
Understanding Clinical Study Designs
05:54
The Role of Observational Studies in Healthcare
Debunking Myths About GLP-1 Medications
YouTube Video DM9Do_V6_sU
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BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

by Daily Remedy
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Can lowering tau biology translate into a clinically meaningful slowing of decline in people with early symptomatic Alzheimer’s disease? That is the practical question behind BIIB080, an intrathecal antisense therapy designed to reduce production of tau protein by targeting the tau gene transcript. In a phase 1b program originally designed for safety and dosing, investigators later examined cognitive, functional, and global outcomes as exploratory endpoints. The clinical question matters because current disease-modifying options primarily target amyloid, while tau pathology tracks...

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