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Home Financial Markets

End of Year Healthcare IPO Bubble

Daily Remedy by Daily Remedy
September 27, 2021
in Financial Markets
0

Every end is the beginning of something new.

As we approach the last quarter (Q4) of 2021, we begin to see more healthcare startups and pending unicorns raise funds at ever higher valuations.

Devoted Health, an insurer that offers personal guidance and healthcare services to patients, is reportedly raising around $1.2 billion at an $11.5 billion valuation. The company has around 40,000 members, which equates to a valuation of $287,000 per member.

To put that into context, last year, Clover Health, another hybrid provider-insurer, became a unicorn at a valuation of $65,000 per member. Brand New Day, another competitor in the space, was acquired last year at $14,600 per member when it had 43,000 members.

Besides the intriguing names of these successful healthcare startups is an equally intriguing rise in valuations. Normally, the success of one startup paves a path for competitor startups and leads to a rise in valuations for all companies within the market. But the rise is not this dramatic.

And whenever we see dramatic rises in valuations, we often think of market bubbles, the inevitable market downturn that takes company valuations with it. Already we see signs of previously highly-valued healthcare startups struggling in the public market.

Oscar Health, a hybrid provider-insurer, lost 45% of its value since going public. The aforementioned Clover Health lost 25% of its value on the public market. Yet the market continues to support higher valuations of healthcare startups.

Inflated valuations that defy market logic and accelerating valuations for pre-IPO startups all point to an inevitable bursting of the healthcare market bubble.

But in our increasingly startup happy healthcare economy, it seems less likely we will see a systemic market downturn, and more likely we will see individual catastrophic flame outs.

Companies with little to no sustainable business model or competitive advantage that manage to raise astronomical sums at implausible valuations. These are the companies to look out for.

They are distinguished by two things – whimsical branding efforts and regulatory risks.

One such potential flame out, Accolade Health, is now entering the virtual primary care market, branding its new service line as personalized healthcare. But there is little to distinguish its virtual healthcare service offerings from other models of telemedicine. It is simply a branding exercise that fails to hold to scrutiny once you get around the catchphrases.

Contrast this marketing gimmick with Oak Street Health, a leading provider of traditional primary care services. Oak Street Health recently inked a deal to be the exclusive provider of AARP Medicare plans. Such deals create a competitive advantage for Oak Street Health by blocking competitors from entering the primary care space.

Companies that fail to achieve similar competitive advantages and rely on marketing slogans will be exposed in the public market. The same goes for companies that succeed on the edges of regulatory risk, including companies that inflate profits through inflated risk assessments of patients.

Recently the Office of Inspector General (OIG) released a report criticizing healthcare service companies for excessively milking Medicare dollars by overinflating the risk in managing their patients. The OIG was particularly critical of United Healthcare, exposing the company’s outsized profits garnered through chart reviews alone.

The bottom line is the fundamentals hold true. Healthcare has fallen in love with startup culture and valuations are rising as a result of that relationship. But the IPO market remains brutal as ever. They will not hesitate to lower the valuation for any company that does not meet its projected earnings.

That come from sustainable business models and defined competitive advantages. Companies that lack either will rely on rebranding existing clinical services as novel or teetering on the edges of regulatory risk.

These are the flame outs, the ones that will implode in the IPO market. To predict who they are, just look at how they market their services and how the government enforces the regulations.

Those tells are the beginning of the end.

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Daily Remedy

Dr. Jay K Joshi serves as the editor-in-chief of Daily Remedy. He is a serial entrepreneur and sought after thought-leader for matters related to healthcare innovation and medical jurisprudence. He has published articles on a variety of healthcare topics in both peer-reviewed journals and trade publications. His legal writings include amicus curiae briefs prepared for prominent federal healthcare cases.

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Videos

This conversation focuses on debunking myths surrounding GLP-1 medications, particularly the misinformation about their association with pancreatic cancer. The speaker emphasizes the importance of understanding clinical study designs, especially the distinction between observational studies and randomized controlled trials. The discussion highlights the need for patients to critically evaluate the sources of information regarding medication side effects and to empower themselves in their healthcare decisions.

Takeaways
GLP-1 medications are not linked to pancreatic cancer.
Peer-reviewed studies debunk misinformation about GLP-1s.
Anecdotal evidence is not reliable for general conclusions.
Observational studies have limitations in generalizability.
Understanding study design is crucial for evaluating claims.
Symptoms should be discussed in the context of clinical conditions.
Not all side effects reported are relevant to every patient.
Observational studies can provide valuable insights but are context-specific.
Patients should critically assess the relevance of studies to their own experiences.
Engagement in discussions about specific studies can enhance understanding

Chapters
00:00
Debunking GLP-1 Medication Myths
02:56
Understanding Clinical Study Designs
05:54
The Role of Observational Studies in Healthcare
Debunking Myths About GLP-1 Medications
YouTube Video DM9Do_V6_sU
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2027 Medicare Advantage & Part D Advance Notice

Clinical Reads

BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

by Daily Remedy
February 15, 2026
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Can lowering tau biology translate into a clinically meaningful slowing of decline in people with early symptomatic Alzheimer’s disease? That is the practical question behind BIIB080, an intrathecal antisense therapy designed to reduce production of tau protein by targeting the tau gene transcript. In a phase 1b program originally designed for safety and dosing, investigators later examined cognitive, functional, and global outcomes as exploratory endpoints. The clinical question matters because current disease-modifying options primarily target amyloid, while tau pathology tracks...

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