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Home Perspectives

What ‘Doing Research’ Really Means

Daily Remedy by Daily Remedy
October 3, 2021
in Perspectives
0

At the edges of science is art, the rationality of science bound within the irrationality of art.

When science goes to its logical extreme, when every cause and effect relationship is traced outwards – to a causeless cause or an unknown effect – logic transforms into faith.

At a certain point, we simply believe what we believe. Only we do not acknowledge it so transparently. When pressed, we find some rationale or stipulation to justify our beliefs.

The concept of beauty is a perfect example. Beauty is fundamentally subjective, based upon personal predilections. But when asked why we find a person attractive, we cite some feature or reference some actor or even refer to the golden ratio – a mythical ratio idealizing the perfect facial proportions.

But beauty is implicit. We either find someone attractive or we do not. We then justify our implicit belief through some explicitly stated reason. But we never conjure reasons that contradict our original belief, only ones that substantiate it.

This is how people think about most things in their lives. And what most people mean when they say they are doing research on matters related to COVID-19.

The novelty of the pandemic has spawned a perception that all treatments and preventative measures related to the pandemic are similarly novel – and as with most novelties in science, seen to be on the cutting edges.

The same edges where science meets art and where logic meets faith. Where beliefs are implicitly generated and then retroactively justified.

We all have watched video clips of a person claiming to need more data or seeming unable to trust the existing data to justify vaccine hesitancy. But in reality, no amount of data or verification of data would overcome the person’s hesitancy. The data is simply the reason stated to justify an implicitly held belief.

We miss this when we discuss pandemic misinformation. The misinformation does not lead a person to hold erroneous opinions. The misinformation allows a person to justify holding erroneous opinions.

Vaccine hesitancy and most of the curious behavioral patterns we find during the pandemic existed long before social media. And for all its pervasiveness, social media is mostly an echo chamber for people to reverberate their existing views more loudly – offering even more reasons to substantiate an originally held implicit belief. Case in point, we pursue media outlets and internet influencers that agree with what we already believe.

We like to claim social media influences our beliefs, or that alternative news outlets affect the way we think, because this is how we explain our implicitly held beliefs.

We recently surveyed readers regarding the likely confluence of both an influenza outbreak and a surge in COVID-19 cases. A majority (60%) acknowledge that the media’s use of the term, twindemic, influences their perception on the likelihood of such an event.

Essentially, the readers claim their beliefs are influenced by the media coining the term, twindemic. This is absurd – irrational, you could say. This is precisely the point.

The implicit beliefs we hold are not rational, but derived through some preconceived notion – logical or not – that we then find reasons to justify when explaining our beliefs to others. Sometimes the original belief is irrational, which means the justification might be irrational, or might be a pretense to appear rational while not actually reflecting the original belief.

When people say they do their own research, they are simply looking for reasons to justify what they already believe. They are not conducting research in the truest sense of the word, weighing all facts and clinical studies to derive at an objective conclusion. They are searching for something to explain their beliefs in way that appears convincible.

This is an art, not a science. This is why scientific discussions or data-driven arguments can never convince people to change their opinions on matters related to COVID-19. For them, the beliefs are a matter of faith – beyond logic, beyond the edges of science, arriving at the point where logic transforms into faith.

Where implicitly held beliefs are defined by the irrationality of art – the art of medicine.

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Daily Remedy

Dr. Jay K Joshi serves as the editor-in-chief of Daily Remedy. He is a serial entrepreneur and sought after thought-leader for matters related to healthcare innovation and medical jurisprudence. He has published articles on a variety of healthcare topics in both peer-reviewed journals and trade publications. His legal writings include amicus curiae briefs prepared for prominent federal healthcare cases.

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Videos

This conversation focuses on debunking myths surrounding GLP-1 medications, particularly the misinformation about their association with pancreatic cancer. The speaker emphasizes the importance of understanding clinical study designs, especially the distinction between observational studies and randomized controlled trials. The discussion highlights the need for patients to critically evaluate the sources of information regarding medication side effects and to empower themselves in their healthcare decisions.

Takeaways
GLP-1 medications are not linked to pancreatic cancer.
Peer-reviewed studies debunk misinformation about GLP-1s.
Anecdotal evidence is not reliable for general conclusions.
Observational studies have limitations in generalizability.
Understanding study design is crucial for evaluating claims.
Symptoms should be discussed in the context of clinical conditions.
Not all side effects reported are relevant to every patient.
Observational studies can provide valuable insights but are context-specific.
Patients should critically assess the relevance of studies to their own experiences.
Engagement in discussions about specific studies can enhance understanding

Chapters
00:00
Debunking GLP-1 Medication Myths
02:56
Understanding Clinical Study Designs
05:54
The Role of Observational Studies in Healthcare
Debunking Myths About GLP-1 Medications
YouTube Video DM9Do_V6_sU
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2027 Medicare Advantage & Part D Advance Notice

Clinical Reads

BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

by Daily Remedy
February 15, 2026
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Can lowering tau biology translate into a clinically meaningful slowing of decline in people with early symptomatic Alzheimer’s disease? That is the practical question behind BIIB080, an intrathecal antisense therapy designed to reduce production of tau protein by targeting the tau gene transcript. In a phase 1b program originally designed for safety and dosing, investigators later examined cognitive, functional, and global outcomes as exploratory endpoints. The clinical question matters because current disease-modifying options primarily target amyloid, while tau pathology tracks...

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