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Study finds timing an issue in combination therapy for COVID-19 patients
February 13, 2021 - 7:30 pm

The SOLIDARITY and RECOVERY trials have shown the efficacy of single agents in Coronavirus disease (COVID-19) patients. Knowledge gaps remain regarding the timing of administration and combination treatment. We searched PubMed without language restriction for studies published from database inception until December 24, 2020, with the terms “SARS-CoV-2″ or ”COVID-19″ and “antiviral” and “lopinavir-ritonavir” and “ribavirin” and “umifenovir” and “interferon” and “steroids” and “antibiotics” and “Chinese medicine” and “intensive care unit” or “invasive mechanical ventilation” or “mortality” or “death” or “length of stay”. No relevant articles pertaining to different therapeutic options for COVID-19 was found.
Source: eClinicalMedicine

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The Fight Over Inoculation During the 1721 Boston Smallpox Epidemic
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Although inoculations were themselves a risky practice and carried a not-insignificant health risk, this data demonstrates that inoculations were significantly less fatal than the naturally occurring virus.


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