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Home Uncertainty & Complexity

Can Medicine Return to its Roots?

Daily Remedy by Daily Remedy
September 6, 2022
in Uncertainty & Complexity
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Can Medicine Return to its Roots?

We complain about medicine so often that it has become a cliché. Yet we do little about it. We might write an article or post something on social media from time to time. But that is it.

It feels like empty pageantry more than anything else. Perhaps that is the point. Complain a bit about a system that is inherently flawed and then go about operating within it. It makes for a convenient balance of justified self-righteousness.

Unfortunately, there is a difference between being self-righteous and being right – between simply talking versus doing something meaningful. We see it when we acknowledge our hypocrisies.

Few in medicine want to change the system. Sure, it may not lead to optimal patient outcomes, but it surely enriches those in positions of power. And they dictate the course of care. Since financial gains come from technological advancements, we have a technological model of medicine.

The purpose of technology is to create data. The purpose of data is to create certainty. Certainty is good for shareholders and financial returns. It is all quite circular.

But it is not good for medicine, which requires uncertainty. Most would assume technology and data are the problem. So let us rid ourselves of that and return to the idealized, pastoral roots of humanistic medicine. That would be wrong and grossly unrealistic. Technology and data are not the problem. It is our use of them.

The two hold value, and have the potential for even greater value if used properly. That sounds overly idealistic and incredibly difficult to define. What is proper in a healthcare system may not be proper for patients. But the problem is more fundamental: we do not even know the context for understanding this term.

That, ironically enough, is why we will find a solution. Medicine is by nature uncertain. We distort it into something concrete because we like to think in terms of certainty. We then take technology and the data derived out of it and force an answer. If we palpate an abdominal mass, then we order an imaging study of the abdomen, visualize the mass, and measure its size. We then determine the course of clinical care off of the numbers.

It is all so simple, so certain – yet somehow proves limited and harmful to patients. In our quest for certainty, we forgot why uncertainty matters in medicine. It explains why we have mounting vaccine hesitancy despite unprecedented technological advancements in vaccine development. Certainty is rational and uncertainty is irrational, consisting of subjective perceptions innate to each of us.

We like data that is rational and when it behaves irrationally, we like to explain it away. We call it things like noise or randomness. Instead, we should call it patient perceptions and explain it to patients. When we diminish their gut feelings, we lose the humanity in medicine.

And we are left with technology and data: outcomes and cash flow statements. When we see it so plainly, we confront an uncomfortable reality and we react polemically, yelling: medicine has lost its way, we need to reset the entire system, and on it goes.

No, we do not need a massive overhaul. We need to realign how we approach technology and data. Divert the two toward medical uncertainty and frame them around what we do not know. This provides a clear delineation between what is known relative to what is unknown.

Known information guides clinical decision-making. Whatever unknown that is acknowledged fosters clinical trust. One leads the way and the other ensures no one is left behind.

To attain this balance is simple enough. Adjust how we look at data and use technology. Right now we obsess over concrete certainty – find the right diagnosis, the best clinical treatment. Instead, use the two to find a balance between a good enough diagnosis, an effective enough treatment, and active patient engagement.

It will lead to better patient outcomes.

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Daily Remedy

Dr. Jay K Joshi serves as the editor-in-chief of Daily Remedy. He is a serial entrepreneur and sought after thought-leader for matters related to healthcare innovation and medical jurisprudence. He has published articles on a variety of healthcare topics in both peer-reviewed journals and trade publications. His legal writings include amicus curiae briefs prepared for prominent federal healthcare cases.

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Videos

This conversation focuses on debunking myths surrounding GLP-1 medications, particularly the misinformation about their association with pancreatic cancer. The speaker emphasizes the importance of understanding clinical study designs, especially the distinction between observational studies and randomized controlled trials. The discussion highlights the need for patients to critically evaluate the sources of information regarding medication side effects and to empower themselves in their healthcare decisions.

Takeaways
GLP-1 medications are not linked to pancreatic cancer.
Peer-reviewed studies debunk misinformation about GLP-1s.
Anecdotal evidence is not reliable for general conclusions.
Observational studies have limitations in generalizability.
Understanding study design is crucial for evaluating claims.
Symptoms should be discussed in the context of clinical conditions.
Not all side effects reported are relevant to every patient.
Observational studies can provide valuable insights but are context-specific.
Patients should critically assess the relevance of studies to their own experiences.
Engagement in discussions about specific studies can enhance understanding

Chapters
00:00
Debunking GLP-1 Medication Myths
02:56
Understanding Clinical Study Designs
05:54
The Role of Observational Studies in Healthcare
Debunking Myths About GLP-1 Medications
YouTube Video DM9Do_V6_sU
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BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

by Daily Remedy
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Can lowering tau biology translate into a clinically meaningful slowing of decline in people with early symptomatic Alzheimer’s disease? That is the practical question behind BIIB080, an intrathecal antisense therapy designed to reduce production of tau protein by targeting the tau gene transcript. In a phase 1b program originally designed for safety and dosing, investigators later examined cognitive, functional, and global outcomes as exploratory endpoints. The clinical question matters because current disease-modifying options primarily target amyloid, while tau pathology tracks...

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