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    How NADAC, WAC, and ASP Shape Drug Costs

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    Public Perception of Peptide Regulation and Compounding Practices

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    How NADAC, WAC, and ASP Shape Drug Costs

    How NADAC, WAC, and ASP Shape Drug Costs

    April 20, 2026
    The Hidden Costs Employers Don’t See in Traditional Health Plans

    The Hidden Costs Employers Don’t See in Traditional Health Plans

    March 22, 2026
    The Impact of COVID-19 on Patient Trust

    The Impact of COVID-19 on Patient Trust

    March 3, 2026
    Debunking Myths About GLP-1 Medications

    Debunking Myths About GLP-1 Medications

    February 16, 2026
    The Future of LLMs in Healthcare

    The Future of LLMs in Healthcare

    January 26, 2026
    The Future of Healthcare Consumerism

    The Future of Healthcare Consumerism

    January 22, 2026
  • Surveys

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    Public Perception of Peptide Regulation and Compounding Practices

    Public Perception of Peptide Regulation and Compounding Practices

    April 19, 2026
    Understanding of Clinical Evidence in Peptide and Hormone Use

    Understanding of Clinical Evidence in Peptide and Hormone Use

    March 30, 2026

    Survey Results

    Can you tell when your provider does not trust you?

    Can you tell when your provider does not trust you?

    January 18, 2026
    Do you believe national polls on health issues are accurate

    National health polls: trust in healthcare system accuracy?

    May 8, 2024
    Which health policy issues matter the most to Republican voters in the primaries?

    Which health policy issues matter the most to Republican voters in the primaries?

    May 14, 2024
    How strongly do you believe that you can tell when your provider does not trust you?

    How strongly do you believe that you can tell when your provider does not trust you?

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Home Politics & Law

Of Approvals and Mandates

Daily Remedy by Daily Remedy
May 7, 2024
in Politics & Law
0

Famed economist Milton Friedman once quipped, “the cure is worse than the disease”, when explaining the federal government’s tendency to worsen rather than to resolve social issues.

Friedman was a firm believer in an independent market, touted the virtues of the individual to self-regulate through capitalistic principles of self-interest, and saw government regulation as an unnecessary intervention that disrupted natural market dynamics.

When Friedman opined about healthcare, he would describe it as an industry held hostage by regulatory interventions. He blamed the exorbitant cost of care to a third party system in which healthcare insurance plans mishandled spending for clinical services, and labeled the federal health insurance program, Medicare, as a form of subsidy.

He believed healthcare would be more cost effective and resourceful if purchasing power went directly into the hands of patients.

But with more purchasing power comes more independent decision-making, and with more independence comes more responsibility, begging the question – are patients responsible enough to make independent decisions concerning their health?

Even in less hectic, pre-pandemic times, the question would be polarizing. But during the pandemic, the question becomes outright inflammatory.

The distinction between patients and consumers has blurred into an interpretive oblivion, with every person possessing self-appointed subject matter expertise for all things pandemic – which of course includes vaccines.

Nearly half the country remains adamant against vaccinations, feeling confident in making medical decisions that appear to be in their best interest, regardless of the medical advice coming from the physician community. The other half is just as adamant for vaccinations, even supporting vaccine mandates for anyone who has not yet been vaccinated.

This is where things stood for weeks as we saw the initial peak of daily vaccinations dwindle to a standstill. Even the rise in delta variant cases produced only a small uptick in vaccinations, and nationwide the vaccination percentages remained largely deadlocked.

A situation those in favor of vaccine mandates believe will change with the recent FDA approval of the Pfizer COVID-19 vaccine. While multiple vaccines have received emergency approval, the Pfizer vaccine is the first to receive full approval.

We caution against such optimism, and we believe Friedman would agree posthumously.

Market approval will have little to no effect on vaccination rates because market approval never had any effect to begin with. When the vaccine was first available, those inclined to receive it, took it, and those inclined otherwise did not take it.

The market has played itself out already.

Why would we expect regulatory approval to influence individual decisions, when those willing to receive the vaccine did not need approval in the first place?

Regulatory bodies have an uncanny ability to be disregarded in the most critical of times. In the early days of the pandemic, patients purchased as many COVID-19 tests as possible – regardless of whether they were approved by the FDA.

Throughout the pandemic, we saw miracle drugs appear and quickly disappear, regardless of the FDA status. First it was hydroxychloroquine, then azithromycin, and most recently, ivermectin. The agency’s approval of the drug, or its intended use, matters less than the patient’s belief in the drug – regardless of whether that belief is founded in sound medical principles.

Patients now act as consumers, making medical decisions independent of any market regulation. And will resist any vaccine mandate regardless of its approval status.

Therefore, the government would be wise to avoid vaccine mandates altogether. Instead, it should opt for less intrusive interventions amenable to current market conditions. Currently, trust in government institutions is at an all time low, and will likely remain low until the end of the pandemic.

Instead of directly engaging with patients, the government should encourage market conditions that favor vaccinations. Many corporations are penalizing its unvaccinated workforce through wage garnishments or weekly testing. The government can support these efforts by providing tax credits to any company enforcing such penalties. Another option would be to help companies provide paid leave for employees to get vaccinated.

Both options would help companies encourage vaccinations and would avoid direct government intervention.

A strategy we hope the government opts for instead of imposing broad vaccine mandates, regardless of the vaccine approval status. As the country grapples with the rising delta variant, we cannot afford to further alienate the unvaccinated population.

If patients wish to act as consumers, then we should apply principles of consumerism towards any government intervention intended to increase vaccination. That means less direct government intervention.

Friedman warned us years ago of the unintended consequences that come with excessive government intervention in healthcare. So far we have ignored these warnings.

We should now heed the warnings, and use traditional market principles to encourage patients to get vaccinated.

Perhaps the market will work more effectively than government mandates. That is, after all, the basis of our capitalistic society.

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Daily Remedy

Daily Remedy

Dr. Jay K Joshi serves as the editor-in-chief of Daily Remedy. He is a serial entrepreneur and sought after thought-leader for matters related to healthcare innovation and medical jurisprudence. He has published articles on a variety of healthcare topics in both peer-reviewed journals and trade publications. His legal writings include amicus curiae briefs prepared for prominent federal healthcare cases.

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Videos

summary

An in-depth exploration of drug pricing, including key databases like NADAC, WAC, and ASP, and how they influence the pharmaceutical supply chain, policy, and patient advocacy. The episode also introduces MedPricer's innovative pricing intelligence platform, offering valuable insights for healthcare professionals, policymakers, and patients.

Chapters

00:00 Understanding Drug Pricing Dynamics
03:52 Exploring the Drug Pricing Database
10:07 Patient Advocacy and Drug Pricing
13:56 Market Intelligence in Drug Pricing
How NADAC, WAC, and ASP Shape Drug CostsDaily Remedy
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Policy Shift in Peptide Regulation

Clinical Reads

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

by Daily Remedy
April 19, 2026
0

Clinicians increasingly encounter patients using or requesting peptide-based therapies sourced through compounding pharmacies. The U.S. Food and Drug Administration has identified a subset of bulk drug substances, including certain peptides, that may present significant safety risks when used in compounded formulations. The clinical question is whether these regulatory signals reflect meaningful patient-level risk and how they should influence prescribing behavior. This matters because compounded peptides often sit outside traditional approval pathways, creating uncertainty around quality, dosing consistency, and safety. Understanding...

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