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    How NADAC, WAC, and ASP Shape Drug Costs

    How NADAC, WAC, and ASP Shape Drug Costs

    April 20, 2026
    The Hidden Costs Employers Don’t See in Traditional Health Plans

    The Hidden Costs Employers Don’t See in Traditional Health Plans

    March 22, 2026
    The Impact of COVID-19 on Patient Trust

    The Impact of COVID-19 on Patient Trust

    March 3, 2026
    Debunking Myths About GLP-1 Medications

    Debunking Myths About GLP-1 Medications

    February 16, 2026
    The Future of LLMs in Healthcare

    The Future of LLMs in Healthcare

    January 26, 2026
    The Future of Healthcare Consumerism

    The Future of Healthcare Consumerism

    January 22, 2026
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    Public Perception of Peptide Regulation and Compounding Practices

    Public Perception of Peptide Regulation and Compounding Practices

    April 19, 2026
    Understanding of Clinical Evidence in Peptide and Hormone Use

    Understanding of Clinical Evidence in Peptide and Hormone Use

    March 30, 2026

    Survey Results

    Can you tell when your provider does not trust you?

    Can you tell when your provider does not trust you?

    January 18, 2026
    Do you believe national polls on health issues are accurate

    National health polls: trust in healthcare system accuracy?

    May 8, 2024
    Which health policy issues matter the most to Republican voters in the primaries?

    Which health policy issues matter the most to Republican voters in the primaries?

    May 14, 2024
    How strongly do you believe that you can tell when your provider does not trust you?

    How strongly do you believe that you can tell when your provider does not trust you?

    May 7, 2024
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  • Home
  • Articles
  • Podcasts
    How NADAC, WAC, and ASP Shape Drug Costs

    How NADAC, WAC, and ASP Shape Drug Costs

    April 20, 2026
    The Hidden Costs Employers Don’t See in Traditional Health Plans

    The Hidden Costs Employers Don’t See in Traditional Health Plans

    March 22, 2026
    The Impact of COVID-19 on Patient Trust

    The Impact of COVID-19 on Patient Trust

    March 3, 2026
    Debunking Myths About GLP-1 Medications

    Debunking Myths About GLP-1 Medications

    February 16, 2026
    The Future of LLMs in Healthcare

    The Future of LLMs in Healthcare

    January 26, 2026
    The Future of Healthcare Consumerism

    The Future of Healthcare Consumerism

    January 22, 2026
  • Surveys

    Surveys

    Public Perception of Peptide Regulation and Compounding Practices

    Public Perception of Peptide Regulation and Compounding Practices

    April 19, 2026
    Understanding of Clinical Evidence in Peptide and Hormone Use

    Understanding of Clinical Evidence in Peptide and Hormone Use

    March 30, 2026

    Survey Results

    Can you tell when your provider does not trust you?

    Can you tell when your provider does not trust you?

    January 18, 2026
    Do you believe national polls on health issues are accurate

    National health polls: trust in healthcare system accuracy?

    May 8, 2024
    Which health policy issues matter the most to Republican voters in the primaries?

    Which health policy issues matter the most to Republican voters in the primaries?

    May 14, 2024
    How strongly do you believe that you can tell when your provider does not trust you?

    How strongly do you believe that you can tell when your provider does not trust you?

    May 7, 2024
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Home Perspectives

Thoughts of a South Side GI

Musings on my ride home

Mahesh Vadali, MD by Mahesh Vadali, MD
May 16, 2024
in Perspectives
0
Thoughts of a South Side GI

Victor Lozano

In this business, the outcomes don’t always follow the efforts. This is something I remind myself when reminiscing on past patients. I remember when my children were young; I spent an entire Christmas Day desperately trying to stem the hemorrhage of an intoxicated person, ultimately in vain. When I went to discuss the situation with the family, I found an inebriated brother in the waiting room. The irony was deflating, but sadly, indicative of many clinical experiences.

For a decade, I was the chief of gastroenterology at a medical center where I was tasked with policing a department without any of requisite authority to do so. With little to no infrastructure in place, I had to navigate adversarial health policies and workplace politics just so I can provide the quality of care I believe my patients deserve.

This experience highlighted the critical importance of healthcare system management in ensuring that the healthcare policy in place supports both patients and providers.

What is portrayed on television or on the big screen has very little to do with the day in, day out life of the average physician in the real world.

The reality is far more grounded in the modern medical practices and the innovations in healthcare that we implement to manage and treat our patients.

Do you know why we bother to do this? It’s because we actually make a difference in the lives of our patients, and in turn, they make a difference in our lives. It’s symbiotic, but for an outsider looking in, it’s outright irrational.

My supervising medical resident during my first month of clinical rotations in my third year of medical school was going into gastroenterology. At the time, I thought that was crazy.

In the medical community, gastroenterology represents the purview of streets and sanitation, where you’re exposed to stool, vomit, blood, pus, and all sorts of fluids of disrepute. You get the point. Yet somehow, it’s the field I ended up. And the perspectives of hindsight give me a newfound appreciation for what I do, echoing the complex interplay of healthcare policy issues and patient rights.

After nearly three decades of practicing as a gastroenterologist on the Southwest side of Chicago, I have been fortunate and privileged to have worked with some incredible colleagues and coworkers, and of course, to have taken care of many wonderful patients.

Last week I diagnosed colon cancer in a patient and referred him to a surgeon. The problem is that no one has been able to contact him for the past week. He doesn’t answer his phone nor return any calls. The surgeon, my staff, and I, among other medical personnel, have tried for a week to reach him. Finally today, I reached someone who is familiar with his condition.

Apparently, the police needed to be called three times before in order to contact him. He seems to have a self-destructive affection for firewater – as those in the know call liquor. But before we jump to conclusions, remember that many times, such patients have experienced so much trauma in their lives that this is the only way they have learned to numb the pain. No level of medical training can teach that empathy. That’s something you have to feel firsthand.

I have another patient who I diagnosed with a precancerous condition a couple of years ago and referred him for curative treatment. He underwent one treatment session. Afterwards, he was informed by his insurance plan that he had failed to obtain proper preauthorization for the treatment, so that the entire process wouldn’t be covered. As a result, he would be responsible for the treatment already rendered. Needless to say, he couldn’t afford to continue the treatment process and never finished it.

By the time I saw him again, I had to inform him that he had developed metastatic cancer. When bad things happen to good people, it’s awful. But when you’re the bearer of the bad news, it’s gut wrenching. It’s the most difficult part of my job and it has nothing to do with medicine.

Don’t get me wrong, I truly love what I do. And I would do it all over again. But it’s not for the faint of heart and certainly requires some intestinal fortitude. We all find ways to cope. For me personally, I immerse myself in the world of my patients. It’s somehow soothing to think as they do. Often that entails listening to music that I would never do otherwise. In that vein, I leave you with a song that’s been playing all weekend:

Stop, drop, shut ’em down, open up shop! That’s how Ruff Ryders roll.

This is how we gastroenterologists roll on the South Side of Chicago. This is how we do it.

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Mahesh Vadali, MD

Mahesh Vadali, MD

Dr. Mahesh Vadali is a gastroenterologist in Oak Lawn, IL, and is affiliated with multiple hospitals in the area. He received his medical degree from McGaw Medical Center of Northwestern University and has been in practice for more than 20 years.

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Videos

summary

An in-depth exploration of drug pricing, including key databases like NADAC, WAC, and ASP, and how they influence the pharmaceutical supply chain, policy, and patient advocacy. The episode also introduces MedPricer's innovative pricing intelligence platform, offering valuable insights for healthcare professionals, policymakers, and patients.

Chapters

00:00 Understanding Drug Pricing Dynamics
03:52 Exploring the Drug Pricing Database
10:07 Patient Advocacy and Drug Pricing
13:56 Market Intelligence in Drug Pricing
How NADAC, WAC, and ASP Shape Drug CostsDaily Remedy
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Policy Shift in Peptide Regulation

Clinical Reads

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

by Daily Remedy
April 19, 2026
0

Clinicians increasingly encounter patients using or requesting peptide-based therapies sourced through compounding pharmacies. The U.S. Food and Drug Administration has identified a subset of bulk drug substances, including certain peptides, that may present significant safety risks when used in compounded formulations. The clinical question is whether these regulatory signals reflect meaningful patient-level risk and how they should influence prescribing behavior. This matters because compounded peptides often sit outside traditional approval pathways, creating uncertainty around quality, dosing consistency, and safety. Understanding...

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