Sunday, February 22, 2026
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A conversation with Dr. Kyle Fischer, emergency medicine physician and gun policy expert

Kyle Fischer, MD, MPH, serves as the policy director for the Health Alliance for Violence Intervention. He leads the organization in coordinating, developing, and advocating for evidence-informed policy to end community violence. Besides this role, he continues to practice as an emergency physician and fellowship director in health policy with the University of Maryland School of Medicine. His interest in violence prevention stems from his emergency medicine residency in Philadelphia, where he volunteered with the Healing Hurt People program.

Daily Remedy

Daily Remedy

Dr. Jay K Joshi serves as the editor-in-chief of Daily Remedy. He is a serial entrepreneur and sought after thought-leader for matters related to healthcare innovation and medical jurisprudence. He has published articles on a variety of healthcare topics in both peer-reviewed journals and trade publications. His legal writings include amicus curiae briefs prepared for prominent federal healthcare cases.

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BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

BIIB080 in Mild Alzheimer’s Disease: What a Phase 1b Exploratory Clinical Analysis Can—and Cannot—Tell Us

Can lowering tau biology translate into a clinically meaningful slowing of decline in people with early symptomatic Alzheimer’s disease? That is the practical question behind BIIB080, an intrathecal antisense therapy designed to reduce production of tau protein by targeting the tau gene transcript. In a phase 1b program originally designed for safety and dosing, investigators later examined cognitive, functional, and global outcomes as exploratory endpoints. The clinical question matters because current disease-modifying options primarily target amyloid, while tau pathology tracks...

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