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    How NADAC, WAC, and ASP Shape Drug Costs

    How NADAC, WAC, and ASP Shape Drug Costs

    April 20, 2026
    The Hidden Costs Employers Don’t See in Traditional Health Plans

    The Hidden Costs Employers Don’t See in Traditional Health Plans

    March 22, 2026
    The Impact of COVID-19 on Patient Trust

    The Impact of COVID-19 on Patient Trust

    March 3, 2026
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    Debunking Myths About GLP-1 Medications

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    January 26, 2026
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    January 22, 2026
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    Public Perception of Peptide Regulation and Compounding Practices

    April 19, 2026
    Understanding of Clinical Evidence in Peptide and Hormone Use

    Understanding of Clinical Evidence in Peptide and Hormone Use

    March 30, 2026

    Survey Results

    Can you tell when your provider does not trust you?

    Can you tell when your provider does not trust you?

    January 18, 2026
    Do you believe national polls on health issues are accurate

    National health polls: trust in healthcare system accuracy?

    May 8, 2024
    Which health policy issues matter the most to Republican voters in the primaries?

    Which health policy issues matter the most to Republican voters in the primaries?

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Home Innovations & Investing

Health Startups: Manage Expectations

Be realistic and win credibility

Arlen Meyers by Arlen Meyers
March 15, 2024
in Innovations & Investing
0
Health Startups Manage Expectations

Headway

Whenever you work with or hire people, it is almost always a good idea to set and clarify expectations. For example, if you are appointing an advisory board for your start up, you should define the deliverables, timelines and roles. Likewise, when you are working on a project, you should set SMART goals-

S – specific, significant, stretching

M – measurable, meaningful, motivational

A – agreed upon, attainable, achievable, acceptable, action-oriented

R – realistic, relevant, reasonable, rewarding, results-oriented

T – time-based, time-bound, timely, tangible, trackable

When it comes to innovating, though, DUMB goals might be better to stretch people a bit.

The same applies when you are leading an innovation initiative. You should be crystal clear about defining and setting expectations. and here are some big reasons why:

1. People have different understandings of innovation: Innovation has both a qualitative and quantitative component and occupies one of four boxes in the novelty-value matrix.

If you want to build a great company, your product has got to be ten times better than the competition.” Today, that advice feels out of date. If you want to build a great company in 2018, your customer experience has to be ten times lighter than the competition. It used to be what you sell that really matters, now it’s how you sell that really matters.

Innovators need to understand where you want them to play.

Tinkerers: low novelty, low value.

A solution looking for a problem: high novelty, low value

Go big or go home: High novelty, high value

Useful but no cigar: High novelty, low-medium value. Some refer to this as a minimally valuable product.

Incremental: Disruption is not the only path to innovation and growth. Creation without disruption or nondisruptive creation is about creating a new market outside or beyond existing industry boundaries and has its own organizational and business advantages. In this article, the authors outline four advantages to opting for this nondisruptive route: 1) It allows you to avoid direct confrontations with established incumbents. 2) It is an effective way to respond to full-on disruption. 3) It makes it easier to secure support from internal stakeholders. 4) It avoids backlash from external stakeholders.

Some incrementalists think that the hard work of health care transformation requires small experiments from the bottom up that redesign care. Others think that instead of tweaking the system, they should try to make it obsolete.

2. It’s hard to boil the ocean. In healthcare, for example, there are multiple ways to create value, but they come down to improving the patient and doctor experience of quality of care and service, reducing per capita costs, and improving population health. Of course, there are also business metrics that improve revenues, reduce costs or capture market share. You also need to be specific about your strategic priorities-cancer care, the injured and aging brain or renal disease- and specific what ideas will be rejected.

3. You need an innovation leadership system that is transparent. A suggestion box won’t work. You have to explain to potential innovators not just what ideas will get consideration, but how and the steps you will take to solicit, vet, and choose ideas to test or implement and how the innovation process will work. There should be no doubt in the mind of potential innovators about what happens next.

4. Everyone seems to have a different understanding of value

5. You should lead innovators, not manage innovation

6. Innovation in organizations happens when intrapreneurs-those with an entrepreneurial mindset- work in a culture of innovation. Consequently, you should make the organizational structures, processes and procedures clear,particularly when it comes to explaining how ideas will be vetted and resourced.

7. Be sure you avoid pilot purgatory and the pitfalls that cause it.

8. Monitor and kill ideas that are not meeting expectations.

9. Identify the right key performance indicators, particularly the clinical ones

10. Celebrate success and the champions, no matter how small.

One thing most everyone agrees on is that innovation starts with the right mindset

Having high innovator expectations might also be a self-fulfilling prophesy, like teachers having high expectations of students.

Innovation, like everything else, needs to be led because freedom, creativity and regulation are often in conflict when people are competing for scarce resources. Just because creativity is about serendipity, unpredictability and happy accidents does not mean that your process should be.

Source: Arlen Meyers MD MBA Substack
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Arlen Meyers

Arlen Meyers

Arlen Meyers, MD, MBA is the President and CEO of the Society of Physician Entrepreneurs on Substack and Editor of Digital Health Entrepreneurship

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Videos

summary

An in-depth exploration of drug pricing, including key databases like NADAC, WAC, and ASP, and how they influence the pharmaceutical supply chain, policy, and patient advocacy. The episode also introduces MedPricer's innovative pricing intelligence platform, offering valuable insights for healthcare professionals, policymakers, and patients.

Chapters

00:00 Understanding Drug Pricing Dynamics
03:52 Exploring the Drug Pricing Database
10:07 Patient Advocacy and Drug Pricing
13:56 Market Intelligence in Drug Pricing
How NADAC, WAC, and ASP Shape Drug CostsDaily Remedy
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Policy Shift in Peptide Regulation

Clinical Reads

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

by Daily Remedy
April 19, 2026
0

Clinicians increasingly encounter patients using or requesting peptide-based therapies sourced through compounding pharmacies. The U.S. Food and Drug Administration has identified a subset of bulk drug substances, including certain peptides, that may present significant safety risks when used in compounded formulations. The clinical question is whether these regulatory signals reflect meaningful patient-level risk and how they should influence prescribing behavior. This matters because compounded peptides often sit outside traditional approval pathways, creating uncertainty around quality, dosing consistency, and safety. Understanding...

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