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    How NADAC, WAC, and ASP Shape Drug Costs

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    Public Perception of Peptide Regulation and Compounding Practices

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    April 19, 2026
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    How NADAC, WAC, and ASP Shape Drug Costs

    How NADAC, WAC, and ASP Shape Drug Costs

    April 20, 2026
    The Hidden Costs Employers Don’t See in Traditional Health Plans

    The Hidden Costs Employers Don’t See in Traditional Health Plans

    March 22, 2026
    The Impact of COVID-19 on Patient Trust

    The Impact of COVID-19 on Patient Trust

    March 3, 2026
    Debunking Myths About GLP-1 Medications

    Debunking Myths About GLP-1 Medications

    February 16, 2026
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    January 26, 2026
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    January 22, 2026
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    Public Perception of Peptide Regulation and Compounding Practices

    April 19, 2026
    Understanding of Clinical Evidence in Peptide and Hormone Use

    Understanding of Clinical Evidence in Peptide and Hormone Use

    March 30, 2026

    Survey Results

    Can you tell when your provider does not trust you?

    Can you tell when your provider does not trust you?

    January 18, 2026
    Do you believe national polls on health issues are accurate

    National health polls: trust in healthcare system accuracy?

    May 8, 2024
    Which health policy issues matter the most to Republican voters in the primaries?

    Which health policy issues matter the most to Republican voters in the primaries?

    May 14, 2024
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The ASC Rate Arbitrage: How Ambulatory Surgery Center Growth Looks in Procedure-Level Price Data

Hospital outpatient departments and ambulatory surgery centers compete for the same procedures at dramatically different price points. MedPricer.org reveals where the arbitrage is largest—and which publicly traded ASC operators are positioned to capture it.

Edebwe Thomas by Edebwe Thomas
April 30, 2026
in Uncategorized
0

The most straightforward structural trade in healthcare investing has been hiding in plain sight for a decade: the same procedure, performed by the same physician, at an ambulatory surgery center costs payers between thirty and sixty percent less than at a hospital outpatient department.

CMS has documented this differential extensively and has been adjusting payment policy accordingly—the site-neutral payment initiative has gradually expanded the list of procedures for which Medicare pays the same regardless of setting. Commercial payers have been moving in the same direction, with varying speed depending on their market leverage relative to hospital systems that control physician referral patterns.

MedPricer.org makes this differential legible at the commercial market level and at the procedure level. By querying negotiated rates for high-volume elective procedures—cataract surgery, knee arthroscopy, colonoscopy, hernia repair—across hospital outpatient departments and freestanding ASCs in the same metropolitan area, an analyst can quantify the price gap that payers face and that drives their interest in steering volume to lower-cost settings.

The investment thesis follows directly. ASC operators—both publicly traded entities and the platforms backed by private equity—are positioned to capture volume migrating from hospital outpatient departments as payers redesign benefit structures to incentivize lower-cost site selection. Publicly traded operators like United Surgical Partners International (a Tenet subsidiary), Surgery Partners, and SurgCenter Development platforms receive payer contract pricing that is, in most markets, substantially lower than hospital outpatient rates for the same procedures.

MedPricer’s market-level analysis allows a fund to identify which geographies have the largest hospital-to-ASC rate differentials—and thus the strongest payer incentive to shift volume. A market where commercial payers are paying hospital outpatient departments 250% of Medicare for colonoscopies while paying ASCs 130% of Medicare has a documented $200 billion addressable market in ASC site-of-care shifting. A market where the differential is 20% has a much weaker payer incentive and correspondingly slower volume migration dynamics.

The counterforce to this thesis is hospital system resistance. Large hospital systems earn substantial margins on outpatient procedures and have responded to ASC competition through several strategies: acquiring or joint-venturing with ASC operators to capture the volume within their own networks, using payer contract negotiations to resist benefit design changes that would steer to freestanding ASCs, and using physician employment to control referral patterns. The success of these countermeasures varies by market, and MedPricer data—which shows whether ASC rates in a given market are converging toward hospital outpatient rates (a sign of hospital counter-leverage) or diverging—provides a leading indicator.

The geographic screen for this strategy prioritizes markets where hospital market concentration is moderate rather than high. In highly concentrated hospital markets, systems have sufficient leverage to resist payer-driven site-of-care shifting and to acquire or partner with ASC competitors. In moderately concentrated markets, payer leverage is more balanced, and the ASC price advantage is more likely to translate into genuine volume migration.

Surgery Partners (SGRY) and similar publicly traded ASC operators are natural vehicles for this thesis, but their operating leverage cuts in both directions. Volume concentration in elective procedures makes their revenue highly sensitive to utilization trends—catastrophically demonstrated during the COVID-19 procedure shutdown. The long-term structural case is strong; the quarterly volatility is real. Rate data from MedPricer can help a fund assess whether a given quarter’s volume miss reflects a durable competitive headwind or a temporary utilization disruption.

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Edebwe Thomas

Edebwe Thomas

Edebwe Thomas explores the dynamic relationship between science, health, and society through insightful, accessible storytelling.

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Videos

summary

An in-depth exploration of drug pricing, including key databases like NADAC, WAC, and ASP, and how they influence the pharmaceutical supply chain, policy, and patient advocacy. The episode also introduces MedPricer's innovative pricing intelligence platform, offering valuable insights for healthcare professionals, policymakers, and patients.

Chapters

00:00 Understanding Drug Pricing Dynamics
03:52 Exploring the Drug Pricing Database
10:07 Patient Advocacy and Drug Pricing
13:56 Market Intelligence in Drug Pricing
How NADAC, WAC, and ASP Shape Drug CostsDaily Remedy
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Policy Shift in Peptide Regulation

Clinical Reads

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

FDA Evaluation of Certain Bulk Drug Substances in Compounding: Clinical Interpretation

by Daily Remedy
April 19, 2026
0

Clinicians increasingly encounter patients using or requesting peptide-based therapies sourced through compounding pharmacies. The U.S. Food and Drug Administration has identified a subset of bulk drug substances, including certain peptides, that may present significant safety risks when used in compounded formulations. The clinical question is whether these regulatory signals reflect meaningful patient-level risk and how they should influence prescribing behavior. This matters because compounded peptides often sit outside traditional approval pathways, creating uncertainty around quality, dosing consistency, and safety. Understanding...

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